Phenobarbitone - serum
Last updated: Sunday, 21, March, 2004
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| Item | Process |
|---|---|
| Specimen | 5 mL blood in plain tube. |
| Method | Chromatography, immunoassay. |
| Therapeutic Interval | 65-170 µmol/L (15-40 mg/L). |
| Application | Therapeutic drug monitoring of phenobarbitone or primidone. |
| Interpretation | Phenobarbitone has a long half-life and a steady state may not be reached for several weeks. Mean half-life is 100 hours (range 50-150 hours). Primidone is metabolised to phenobarbitone. |
| Reference | Glauser TA and Pippenger CE. Epilepsia 2000; 41(8): 6-15. |