Primidone - serum

Last updated: Saturday, 20, March, 2004

MBS Online Search Page: Click here for details

Item Process
Specimen5 mL blood in plain tube.

Chromatography or immunoassay.

Therapeutic Interval

22-50 µmol/L (4.8-11.0 mg/L).

ApplicationTherapeutic drug monitoring.
InterpretationPhenobarbitone is an active metabolite of primidone and the level of phenobarbitone is often measured as well as, or instead of, primidone. Steady state level of primidone is reached after 48 hours. Mean half-life 10 hours (range 3-20 hours).

Cloyd JC et al. Clin Pharmacol Ther 1981; 29: 402-407.