Procainamide - serum
Last updated: Thursday, 25, March, 2004
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|Specimen||5 mL blood in plain tube, collected as a trough level immediately prior to next dose.|
|Method||Chromatography or immunoassay.|
| Therapeutic Interval|
Procainamide: 17-42 mmol/L (4-10 mg/L)
Therapeutic drug monitoring.
Both procainamide and its major metabolite N-acetyl procainamide are active pharmacologically and should be measured as the relative levels differ in slow or fast acetylators.
Procainamide half-life is about 3 hours, whereas N-acetylprocainamide has a half-life of about 6-9 hours.
|Reference||Karlsson E. Clin Pharmcokinet 1978; 3: 97-107.|