Protein (total) - urine

Last updated: Saturday, 20, March, 2004

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Item Process
Specimen

Random urine specimen or 24 hour urine collection.

Method

Spectrophotometry.

Reference Interval

<150 mg/24 hours; pregnancy: <250 mg/24 hours.

Application

Assessment of renal disease. Some methods will not detect light chain proteinuria; see Protein electrophoresis - urine.

Interpretation

Protein loss in the urine is most commonly due to renal glomerular disease, esp if >2 g/24 hours. Proteinuria of >3 g/24 hours is required to establish the diagnosis of the nephrotic syndrome. In renal tubular disease, light chain proteinuria, orthostatic proteinuria and myoglobinuria, protein loss is usually <1 g/24 hours. See also Urinalysis.

Reference

Beetham R and Cattell WR. Ann Clin Biochem 1993; 30: 425-434.