Somatostatin - plasma

Last updated: Saturday, 27, March, 2004

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Item Process
Specimen

10 mL blood in a lithium heparin tube.

Plasma must be stored frozen until assay.

Method

Immunoassay.

Reference Interval
90-150 ng/L.
Application

Diagnosis of functional somatostatinoma (diabetes mellitus, cholelithiasis, steatorrhoea, hypochlorhydria).

Functional tumours usually occur as islet cell tumours in the pancreas. Some non-functional somatostatinomas (usually duodenal) may be diagnosed by an increase in somatostatin after infusion of calcium and pentagastrin.

Interpretation

Hypersomatostatinaemia with a somatostatinoma syndrome and a pancreatic tumour is diagnostic of a functional somatostatinoma.

Reference

Tomassetti P et al. Ann Oncol 2001; 2: 95-99.