Sucrose tolerance test - plasma

Last updated: Saturday, 27, March, 2004

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Item Process
Specimen

2 mL blood in lithium heparin tube taken pre-test and at half hourly intervals during test.

Method

Spectrophotometry.

Sucrose tolerance can also be assessed by measurement of breath hydrogen every half hour for three hours after the sucrose is administered. See Hydrogen - breath.

Protocol

The patient takes 1 g sucrose per kg body weight, up to a maximum of 50 g, in a flavoured drink over 10 minutes.

Blood specimens are taken pre-test and half hourly for two hours.

The specimens are analysed for glucose (by spectrophotometry).

Reference Interval

>1.0 mmol/L rise in plasma glucose.

Application

Investigation of sucrose intolerance.

As the test often results in diarrhoea and abdominal pain in affected individuals it has been generally superseded by the assay of sucrase in a small bowel biopsy.
See Disaccharidases - small bowel mucosa.

Interpretation

A subnormal rise in plasma glucose indicates sucrose intolerance.

Reference

Perman JA et al. J Pediatr 1978; 93: 17-22.