Thyroglobulin - serum
Last updated: Tuesday, 30, March, 2004
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5 mL blood in plain tube.
| Reference Interval|
<38 µg/L. Thyroglobulin should be undetectable in a patient who has had a total thyroidectomy.
Detection of tumour recurrence in thyroid cancer.
Investigation of suspected thyroiditis or thyrotoxicosis factitia.
Detectable levels in patients with thyroid cancer who have had a total thyroidectomy (and who should cease thyroid replacement therapy for 2 weeks prior to testing) indicates the presence of residual tumour.
Stimulation with recombinant TSH prior to testing has been recommended. Levels in thyroiditis and thyrotoxicosis are high, but if thyrotoxicosis is due to self-medication with thyroid hormone, the level is suppressed.
Mazzaferri EL et al. J Clin Endocrinol Metab 2003; 88(4): 1433-1441.