Vitamin D (1,25-dihydroxy) - serum

Last updated: Wednesday, 31, March, 2004

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Item Process
Specimen

5 mL blood in a plain tube.

Method

Immunoassay.

Reference Interval

35-120 pmol/L.

Application

Suspected abnormality of vitamin D, not affecting 25-hydroxycholecalciferol. The assay is rarely required clinically.

Interpretation

Normal levels of 25-hydroxycholecalciferol with increased 1,25-dihydroxycholecalciferol levels may be seen in patients with sarcoidosis and after excessive calcitriol intake.

Low levels are seen in some forms of hereditary rickets.

Reference

Rosen JF and Chesney RW. J Pediatr 1983; 103: 1-17.

Sharma OP. Curr Opin Pulm Med 2000; 6(5): 442-447.