Chymotrypsin - faeces
Last updated: Wednesday, 31, March, 2004
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5 g faeces (random) frozen immediately after collection.
Some laboratories may assay trypsin which requires a different substrate.
Both are being replaced by specific assays for human pancreatic elastase.
| Reference Interval|
Diagnosis of pancreatic exocrine failure. Assessment of pancreatic enzyme replacement.
Faecal trypsin and chymotrypsin are reduced in pancreatic exocrine failure.
Malabsorption and decreased faecal enzymes are not usually obvious until >95% of the pancreas has been destroyed.
Petersen JM and Forsmark CE. Semin Gastrointest Dis 2002; 13(4): 191-199.
Layer P et al. Curr Gastroenterol Rep 2001; 3(2): 101-108.