Homovanillate (HVA) - urine

Last updated: Wednesday, 31, March, 2004

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Item Process
Specimen

Random urine collection.

Method

HPLC (creatinine is assayed also, and the result expressed as a ratio, HVA/creatinine).

Reference Interval

Depends on age - consult pathologist.

Application

Diagnosis and monitoring of neuroblastoma and ganglioneuroma.

Interpretation

Levels are increased in most but not all of these tumours.

See also Catecholamines - urine and HMMA - urine.

Reference

O’Meara AO et al. Acta Paediatr 1994; 83: 88-92.

Goldstein DS et al. J Pharmacol Exp Ther 2003; 305(3): 800-811.