Methaemoglobin, sulphaemoglobin - blood
Last updated: Wednesday, 28, April, 2004
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5 mL blood in EDTA.
Spectroscopic screening and spectrophotometric quantitation.
See also Haemoximetry.
| Reference Interval|
Methaemoglobin <1% of total haemoglobin in normal blood, slightly higher in infants, particularly if premature.
Sulphaemoglobin is not present in normal blood.
Investigation of unexplained central cyanosis; possible oxidant drug haemolysis (eg, sulphonamides, aniline dyes, nitrates and nitrites).
Increased levels of methaemoglobin are seen in patients with Hb M haemoglobinopathy or methaemoglobin-reductase deficiency and following oxidant drug exposure.
Sulphaemoglobin may occur with exposure to certain drugs especially sulphonamides.
Bradberry SM. Toxicol Rev 2003; 22(1): 13-27.