Myoglobin - plasma or serum

Last updated: Monday, 22, March, 2004

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Item Process
Specimen

5 mL blood in lithium heparin or plain tube.

Method

Immunoassay.

Reference Interval

< 70 µg/L.

Application

Early detection of myocardial infarction.

Interpretation

Increased levels are found in any condition causing muscle cell damage including myocardial infarction.

Myoglobin levels rise rapidly following myocardial infarction, peaking by about 90 minutes, but the protein is cleared rapidly by the kidneys.

This test is non-specific and, if myocardial infarction is suspected, any raised value should be followed by a troponin assay.

Levels are also increased in patients with rhabdomyolysis but urine myoglobin suffices to confirm myoglobinuria and is the preferred test.

Reference

Plebani M. Clin Chim Acta 2001; 311(1): 3-7.