Fibrinogen - plasma

Last updated: Friday, 02, April, 2004
Item Process
Specimen

4.5 mL blood in 0.5 mL citrate.

Method

Tests based on thrombin clotting time are in common use.

Also, heat precipitation and immunoassay

Reference Interval

1.5-4.0 g/L. Some variation with method.

Application

Investigation of possible acquired or inherited bleeding disorder.

Interpretation

Low levels indicate reduced production (liver disease, inherited deficiency) or increased consumption (DIC, fibrinolysis). Levels are elevated in an acute phase response.

A discrepancy between functional and immunological methods is found in the presence of FDP, and in dysfibrinogenaemia.

Reference

Exner T et al. Am J Clin Pathol 1979; 71: 521-527.