HER-2 (c-erb B-2) Immunostaining
Last updated: Wednesday, 08, August, 2007
Formalin-fixed paraffin embedded breast tissue.
Standar immunohistochemical staining with graded positive and negative on-slide control tissue.
Over expression of HER-2 protein occurs in 10 to 40% of primary breast carcinoma. Immunostaining is undertaken for identification of HER-2 positive tumours and assessment of response to recombinant humanised anti-HER-2 antibody (HerceptinTM) therapy.
Demonty G, Bernard-Marty C, Puglisi F, et al. Progress and new standards of care in management of HER-2 positive breast cancer. Europ J Cancer 43: 497-509, 2007.