Cardiac (endomyocardial) biopsy

Last updated: Wednesday, 08, August, 2007
Item Process
Specimen

Endomyocardial biopsies are usually taken from the right ventricle. Four to six tissue fragments should be submitted.

Method

Specimen submitted in 10% formal saline. In acute cardiac rejection frozen section may be contemplated although rapid paraffin processing is preferable.

Application

Assessment of allograft rejection with biopsies taken according to a standard protocol. Also utilized in diagnostic investigation of cardiomyopathy, myocarditis and cariac amyloid.

Interpretation

Procedure often limited to specialist centres. Consult with pathologist prior to biopsy procedure.

Reference

Silver MD, Gotlieb AI, Schoen FJ. Cardiovascular Pathology. Third Edition. Churchill Livingstone, 2001.