Endomysial antibodies (IgA)

Last updated: Thursday, 25, October, 2007
Item Process
Specimen

5ml blood in plain tube

Method

Immunoassay

Reference Interval

Consult laboratory

Application

Diagnosis of coeliac disease and dermatitis herpetiformis.

Interpretation

Transglutaminase antibodies (IgA) have a specificity of greater than 90% for diagnosis of coeliac disease. The test may be negative in patients with coeliac disease assiciated with IgA deficiency. IgA transglutaminase antibodies have largely superseded endosymial antibodies in the diagnosis of coeliac disease.

IgG transglutaminase antibodies may have some role in diagnosis of coeliac disease in patients with IgA deficiency.

Reference

Wong R et al, Antibody and Genetic Testing in Coeliac Disease, Pathology Aug 2003 285 - 304