Histone antibodies - serum

Last updated: Monday, 22, March, 2004

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Item Process
Specimen

5 mL blood in plain tube.

Method

Immunoassay.

Application

To define specificity of ANA.

Classically histone antibodies give a homogeneous pattern on indirect IF.

Interpretation

Histone antibodies are of limited value in distinguishing between SLE and drug-induced lupus. Although present in 100% of procainamide-induced lupus they also occur in 20% of patients with SLE.

Reference

Adams, B et al. Int J Dermatol 2000; 39:12 887-891.