Immunoglobulins G, A, M - serum

Last updated: Wednesday, 17, March, 2004
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5 mL blood in plain tube.



Reference Interval

Varies with age - see Table 2.


Assessment of patients with recurrent sinopulmonary infection, sepsis, gastrointestinal infection or other clinical presentations suggestive of immunoglobulin deficiency.

Electrophoresis ± immunofixation is required to exclude the presence of a paraprotein.

Detection of hypogammaglobulinaemia and monitoring immunoglobulin levels in patients with multiple myeloma or chronic lymphocytic leukaemia.


Normal immunoglobulin levels do not exclude humoral immunodeficiency.

Further studies, such as assessment of antibody response following administration of vaccines and/or IgG subclasses, may be required if there is a high degree of clinical suspicion.


Check IJ and Papadea C. In: Rose NR et al eds. Manual of Clinical Laboratory Immunology. 5th ed. 1998.