Enterovirus antibodies - serum

Last updated: Saturday, 03, April, 2004

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Item Process
Specimen

5-10 mL blood in plain tube.

Method

Neutralisation (serotype specific), EIA.

Application

Of limited value in the diagnosis of myocarditis, encephalitis, aseptic meningitis, pleurodynia.

Viral isolation or detection of nucleic acid after amplification (nasopharyngeal aspirate or CSF, as appropriate) is more satisfactory.

With the increasing availability of PCR very few laboratories still perform enterovirus serology.

Interpretation

The enterovirus group includes Coxsackieviruses A and B and echoviruses.

Antibody tresting is of very limited usefulness because of the numerous (>70) serotypes.

Occasionally useful in the diagnosis of hand-foot-mouth disease, but this is usually a clinical diagnosis.

Reference

Romero JR and Rotbart HA. In: Murray PR et al eds. Manual of Clinical Microbiology. 8th ed. ASM Press 2003.